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Controlling the Specificity of Modularly Assembled Small Molecules for RNA via Ligand Module Spacing: Targeting the RNAs that Cause Myotonic Muscular Dystrophy
Myotonic muscular dystrophy types 1 and 2 (DM1 and DM2, respectively) are caused by expansions of repeating nucleotides in non-coding regions of RNA. In DM1, the expansion is an rCUG triplet repeat whereas the DM2 expansion is an rCCUG quadruplet repeat, both of which fold into hairpin structures wi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2801143/ https://ncbi.nlm.nih.gov/pubmed/19904940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja906877y |
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