Controlling the Specificity of Modularly Assembled Small Molecules for RNA via Ligand Module Spacing: Targeting the RNAs that Cause Myotonic Muscular Dystrophy

Myotonic muscular dystrophy types 1 and 2 (DM1 and DM2, respectively) are caused by expansions of repeating nucleotides in non-coding regions of RNA. In DM1, the expansion is an rCUG triplet repeat whereas the DM2 expansion is an rCCUG quadruplet repeat, both of which fold into hairpin structures wi...

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Bibliographic Details
Main Authors: Lee, Melissa M., Childs-Disney, Jessica L., Pushechnikov, Alexei, French, Jonathan M., Sobczak, Krzysztof, Thornton, Charles A., Disney, Matthew D.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801143/
https://ncbi.nlm.nih.gov/pubmed/19904940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja906877y
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