A carregar...
Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: Application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3
Herein, we describe the design of high affinity ligands that bind expanded rCUG- and rCAG-repeat RNAs expressed in myotonic dystrophy and spinocerebellar ataxia. These ligands also inhibit, with nanomolar IC(50)'s, the formation of RNA-protein complexes that are implicated in both disorders. Th...
Na minha lista:
| Main Authors: | , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2731475/ https://ncbi.nlm.nih.gov/pubmed/19552411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9020149 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|