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Rationally Designed Small Molecules Targeting the RNA That Causes Myotonic Dystrophy Type 1 Are Potently Bioactive

RNA is an important drug target, but it is difficult to design or discover small molecules that modulate RNA function. In the present study, we report that rationally designed, modularly assembled small molecules that bind the RNA that causes myotonic dystrophy type 1 (DM1) are potently bioactive in...

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Hlavní autoři: Childs-Disney, Jessica L., Hoskins, Jason, Rzuczek, Suzanne G., Thornton, Charles A., Disney, Matthew D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356481/
https://ncbi.nlm.nih.gov/pubmed/22332923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200408a
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