Design of a Bioactive Small Molecule that Targets the Myotonic Dystrophy Type 1 RNA Via an RNA Motif-Ligand Database & Chemical Similarity Searching

Myotonic dystrophy type 1 (DM1) is a triplet repeating disorder caused by expanded CTG repeats in the 3′ untranslated region of the dystrophia myotonica protein kinase (DMPK) gene. The transcribed repeats fold into an RNA hairpin with multiple copies of a 5′CUG/3′GUC motif that binds the RNA splicin...

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Detalhes bibliográficos
Main Authors: Parkesh, Raman, Childs-Disney, Jessica L., Nakamori, Masayuki, Kumar, Amit, Wang, Eric, Wang, Thomas, Hoskins, Jason, Tran, Tuan, Housman, David, Thornton, Charles A., Disney, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306011/
https://ncbi.nlm.nih.gov/pubmed/22300544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja210088v
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