A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity

Telomerase is a specialized reverse transcriptase that adds telomeric DNA repeats onto chromosome termini. Here, we characterize a new telomerase-specific motif, called motif 3, in the catalytic domain of telomerase reverse transcriptase, that is crucial for telomerase function and evolutionally con...

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Hauptverfasser: Xie, Mingyi, Podlevsky, Joshua D., Qi, Xiaodong, Bley, Christopher J., Chen, Julian J.-L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
Schlagworte:
Molecular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847249/
https://ncbi.nlm.nih.gov/pubmed/20044353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1198
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