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RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency

Telomerase synthesizes telomeric DNA repeats onto chromosome termini from an intrinsic RNA template. The processive synthesis of DNA repeats relies on a unique, yet poorly understood, mechanism whereby the telomerase RNA template translocates and realigns with the DNA primer after synthesizing each...

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Main Authors: Qi, Xiaodong, Xie, Mingyi, Brown, Andrew F, Bley, Christopher J, Podlevsky, Joshua D, Chen, Julian J-L
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252576/
https://ncbi.nlm.nih.gov/pubmed/21989387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.363
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