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RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency
Telomerase synthesizes telomeric DNA repeats onto chromosome termini from an intrinsic RNA template. The processive synthesis of DNA repeats relies on a unique, yet poorly understood, mechanism whereby the telomerase RNA template translocates and realigns with the DNA primer after synthesizing each...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3252576/ https://ncbi.nlm.nih.gov/pubmed/21989387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.363 |
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