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A single nucleotide incorporation step limits human telomerase repeat addition activity
Human telomerase synthesizes telomeric DNA repeats (GGTTAG)(n) onto chromosome ends using a short template from its integral telomerase RNA (hTR). However, telomerase is markedly slow for processive DNA synthesis among DNA polymerases. We report here that the unique template‐embedded pause signal re...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5852417/ https://ncbi.nlm.nih.gov/pubmed/29440226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201797953 |
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