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Eribulin Binds at Microtubule Ends to a Single Site on Tubulin to Suppress Dynamic Instability
Eribulin mesylate (E7389), a synthetic analog of the marine natural product halichondrin B, is in Phase III clinical trials for the treatment of cancer. Eribulin targets microtubules, suppressing dynamic instability at microtubule plus ends through an inhibition of microtubule growth with little or...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2846717/ https://ncbi.nlm.nih.gov/pubmed/20030375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901810u |
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