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Eribulin Binds at Microtubule Ends to a Single Site on Tubulin to Suppress Dynamic Instability

Eribulin mesylate (E7389), a synthetic analog of the marine natural product halichondrin B, is in Phase III clinical trials for the treatment of cancer. Eribulin targets microtubules, suppressing dynamic instability at microtubule plus ends through an inhibition of microtubule growth with little or...

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Detalhes bibliográficos
Main Authors: Smith, Jennifer A., Wilson, Leslie, Azarenko, Olga, Zhu, Xiaojie, Lewis, Bryan M., Littlefield, Bruce A., Jordan, Mary Ann
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846717/
https://ncbi.nlm.nih.gov/pubmed/20030375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901810u
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