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Inhibition of Centromere Dynamics by Eribulin (E7389) during Mitotic Metaphase

Eribulin (E7389), a synthetic analog of halichondrin B in Phase III clinical trials for breast cancer, binds to tubulin and microtubules. At low concentrations, it suppresses the growth phase of microtubule dynamic instability in interphase cells, arrests mitosis, and induces apoptosis, suggesting t...

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Main Authors: Okouneva, Tatiana, Azarenko, Olga, Wilson, Leslie, Littlefield, Bruce A., Jordan, Mary Ann
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562299/
https://ncbi.nlm.nih.gov/pubmed/18645010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0095
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