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Inhibition of Centromere Dynamics by Eribulin (E7389) during Mitotic Metaphase

Eribulin (E7389), a synthetic analog of halichondrin B in Phase III clinical trials for breast cancer, binds to tubulin and microtubules. At low concentrations, it suppresses the growth phase of microtubule dynamic instability in interphase cells, arrests mitosis, and induces apoptosis, suggesting t...

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Detalhes bibliográficos
Main Authors: Okouneva, Tatiana, Azarenko, Olga, Wilson, Leslie, Littlefield, Bruce A., Jordan, Mary Ann
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562299/
https://ncbi.nlm.nih.gov/pubmed/18645010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0095
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