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Inhibition of Centromere Dynamics by Eribulin (E7389) during Mitotic Metaphase

Eribulin (E7389), a synthetic analog of halichondrin B in Phase III clinical trials for breast cancer, binds to tubulin and microtubules. At low concentrations, it suppresses the growth phase of microtubule dynamic instability in interphase cells, arrests mitosis, and induces apoptosis, suggesting t...

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Bibliografski detalji
Glavni autori: Okouneva, Tatiana, Azarenko, Olga, Wilson, Leslie, Littlefield, Bruce A., Jordan, Mary Ann
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562299/
https://ncbi.nlm.nih.gov/pubmed/18645010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0095
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