Distinct Pose of Discodermolide in Taxol Binding Pocket Drives a Complementary Mode of Microtubule Stabilization

The microtubule cytoskeleton has proven to be an effective target for cancer therapeutics. One class of drugs, known as microtubule stabilizing agents (MSAs), binds to microtubule polymers and stabilizes them against depolymerization. The prototype of this group of drugs, Taxol, is an effective chem...

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Главные авторы: Khrapunovich-Baine, Marina, Menon, Vilas, Verdier-Pinard, Pascal, Smith, Amos B., Angeletti, Ruth Hogue, Fiser, Andras, Horwitz, Susan Band, Xiao, Hui
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845443/
https://ncbi.nlm.nih.gov/pubmed/19863156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901351q
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