Improved Dose-Response Relationship of (+)-Discodermolide-Taxol Hybrid Congeners

(+)-Discodermolide is a microtubule-stabilizing agent with potential for the treatment of taxol-refractory malignancies. (+)-Discodermolide congeners containing the C-3′-phenyl side chain of taxol (paclitaxel) were synthesized based on computational docking models predicting this moiety would fill a...

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Bibliographic Details
Published in:J Nat Prod
Main Authors: Nadaradjane, Celine, Yang, Chia-Ping Huang, Rodriguez-Gabin, Alicia, Ye, Kenny, Sugasawa, Keizo, Atasoylu, Onur, Smith, Amos B., Horwitz, Susan Band, McDaid, Hayley M.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026530/
https://ncbi.nlm.nih.gov/pubmed/29522336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.8b00111
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