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Improved Dose-Response Relationship of (+)-Discodermolide-Taxol Hybrid Congeners
(+)-Discodermolide is a microtubule-stabilizing agent with potential for the treatment of taxol-refractory malignancies. (+)-Discodermolide congeners containing the C-3′-phenyl side chain of taxol (paclitaxel) were synthesized based on computational docking models predicting this moiety would fill a...
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| Izdano u: | J Nat Prod |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6026530/ https://ncbi.nlm.nih.gov/pubmed/29522336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.8b00111 |
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