Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence

The natural product (+)-discodermolide (DDM) is a microtubule stabilizing agent and potent inducer of senescence. We refined the structure of DDM and evaluated the activity of novel congeners in triple negative breast and ovarian cancers, malignancies that typically succumb to taxane resistance. Pre...

全面介紹

Na minha lista:
書目詳細資料
發表在:Mol Pharmacol
Main Authors: Guo, Boying, Rodriguez-Gabin, Alicia, Prota, Andrea E., Mühlethaler, Tobias, Zhang, Nan, Ye, Kenny, Steinmetz, Michel O., Horwitz, Susan Band, Smith, Amos B., McDaid, Hayley M.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2020
主題:
Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362599/
https://ncbi.nlm.nih.gov/pubmed/32591477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.117457
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍