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Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1–dependent
Discodermolide is a microtubule-stabilizing agent that induces accelerated cell senescence. A discodermolide-resistant cell line, AD32, was generated from the human lung cancer cell line A549. We hypothesize that the major resistance mechanism in these cells is escape from accelerated senescence. AD...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
National Academy of Sciences
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3017154/ https://ncbi.nlm.nih.gov/pubmed/21173253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016962108 |
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