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Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1–dependent
Discodermolide is a microtubule-stabilizing agent that induces accelerated cell senescence. A discodermolide-resistant cell line, AD32, was generated from the human lung cancer cell line A549. We hypothesize that the major resistance mechanism in these cells is escape from accelerated senescence. AD...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3017154/ https://ncbi.nlm.nih.gov/pubmed/21173253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016962108 |
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