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Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1–dependent

Discodermolide is a microtubule-stabilizing agent that induces accelerated cell senescence. A discodermolide-resistant cell line, AD32, was generated from the human lung cancer cell line A549. We hypothesize that the major resistance mechanism in these cells is escape from accelerated senescence. AD...

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Autors principals: Chao, Suzan K., Lin, Juan, Brouwer-Visser, Jurriaan, Smith, Amos B., Horwitz, Susan Band, McDaid, Hayley M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017154/
https://ncbi.nlm.nih.gov/pubmed/21173253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1016962108
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