Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence

The natural product (+)-discodermolide (DDM) is a microtubule stabilizing agent and potent inducer of senescence. We refined the structure of DDM and evaluated the activity of novel congeners in triple negative breast and ovarian cancers, malignancies that typically succumb to taxane resistance. Pre...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Pharmacol
Main Authors: Guo, Boying, Rodriguez-Gabin, Alicia, Prota, Andrea E., Mühlethaler, Tobias, Zhang, Nan, Ye, Kenny, Steinmetz, Michel O., Horwitz, Susan Band, Smith, Amos B., McDaid, Hayley M.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2020
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362599/
https://ncbi.nlm.nih.gov/pubmed/32591477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.117457
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