Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

Talin is a 270-kDa protein that activates integrins and couples them to cytoskeletal actin. Talin contains an N-terminal FERM domain comprised of F1, F2 and F3 domains, but it is atypical in that F1 contains a large insert and is preceded by an extra domain F0. Although F3 contains the binding site...

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Autori principali: Goult, Benjamin T, Bouaouina, Mohamed, Elliott, Paul R, Bate, Neil, Patel, Bipin, Gingras, Alexandre R, Grossmann, J Günter, Roberts, Gordon C K, Calderwood, David A, Critchley, David R, Barsukov, Igor L
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845276/
https://ncbi.nlm.nih.gov/pubmed/20150896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.4
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