High frequency of p53/MDM2/p14(ARF) pathway abnormalities in relapsed neuroblastoma

PURPOSE: Most neuroblastomas initially respond to therapy but many relapse with chemoresistant disease. p53 mutations are rare in diagnostic neuroblastomas, but we have previously reported inactivation of the p53/MDM2/p14(ARF) pathway in 9/17 (53%) neuroblastoma cell lines established at relapse. HY...

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Hauptverfasser: Carr-Wilkinson, Jane, O' Toole, Kieran, Wood, Katrina M., Challen, Christine C., Baker, Angela G., Board, Julian R., Evans, Laura, Cole, Michael, Cheung, Nai-Kong V., Boos, Joachim, Köhler, Gabriele, Leuschner, Ivo, Pearson, Andrew D.J., Lunec, John, Tweddle, Deborah A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842933/
https://ncbi.nlm.nih.gov/pubmed/20145180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1865
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