Structurally diverse MDM2–p53 antagonists act as modulators of MDR-1 function in neuroblastoma

BACKGROUND: A frequent mechanism of acquired multidrug resistance in human cancers is overexpression of ATP-binding cassette transporters such as the Multi-Drug Resistance Protein 1 (MDR-1). Nutlin-3, an MDM2–p53 antagonist, has previously been reported to be a competitive MDR-1 inhibitor. METHODS:...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Chen, L, Zhao, Y, Halliday, G C, Berry, P, Rousseau, R F, Middleton, S A, Nichols, G L, Del Bello, F, Piergentili, A, Newell, D R, Lunec, J, Tweddle, D A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134492/
https://ncbi.nlm.nih.gov/pubmed/24921920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.325
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados