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MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63
MYCN amplification is a major biomarker of poor prognosis, occurring in 25-30% of neuroblastomas. MYCN plays contradictory roles in promoting cell growth and sensitizing cells to apoptosis. We have recently shown that p53 is a direct transcriptional target of MYCN in neuroblastoma and that p53-media...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3191119/ https://ncbi.nlm.nih.gov/pubmed/21725357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.270 |
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