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Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma

Neuroblastoma is a predominantly p53 wild-type (wt) tumour and MDM2-p53 antagonists offer a novel therapeutic strategy for neuroblastoma patients. RG7388 (Roche) is currently undergoing early phase clinical evaluation in adults. This study assessed the efficacy of RG7388 as a single-agent and in com...

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Библиографические подробности
Опубликовано в: :Oncotarget
Главные авторы: Chen, Lindi, Rousseau, Raphaël F., Middleton, Steven A., Nichols, Gwen L., Newell, David R., Lunec, John, Tweddle, Deborah A.
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496350/
https://ncbi.nlm.nih.gov/pubmed/25844600
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