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The MDM2 small-molecule inhibitor RG7388 leads to potent tumor inhibition in p53 wild-type neuroblastoma

Neuroblastoma is an aggressive pediatric malignancy which is >98% p53 wild-type at diagnosis. As a primary repressor of p53 activity and part of a p53-activated negative feedback loop, targeting of mouse double minute 2 homolog (MDM2) is an attractive therapeutic approach to reactivation of p53....

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Detalhes bibliográficos
Publicado no:Cell Death Discov
Main Authors: Lakoma, A, Barbieri, E, Agarwal, S, Jackson, J, Chen, Z, Kim, Y, McVay, M, Shohet, J M, Kim, E S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794278/
https://ncbi.nlm.nih.gov/pubmed/26998348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2015.26
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