MDM2 inhibitor RG7388 potently inhibits tumors by activating p53 pathway in nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a high-risk head and neck cancer with poor clinical outcomes and insufficient treatments. The mouse double minute 2 homolog (MDM2) is the main molecular target in the clinical treatment of cancer. Indeed, MDM2 negatively regulates p53 through ubiquitin-dependent deg...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: Fan, Xiaoqin, Wang, Yujie, Song, Jian, Wu, Hanwei, Yang, Ming, Lu, Lu, Weng, Xin, Liu, Lusha, Nie, Guohui
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783115/
https://ncbi.nlm.nih.gov/pubmed/31311404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2019.1638677
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