p53 is a Direct Transcriptional Target of MYCN in Neuroblastoma

MYCN amplification occurs in around 25% of neuroblastomas, and is associated with rapid tumor progression and poor prognosis. MYCN plays a paradoxical role in driving cellular proliferation and inducing apoptosis. We previously observed nuclear p53 accumulation in neuroblastoma and hypothesize that...

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Bibliographic Details
Main Authors: Chen, Lindi, Iraci, Nunzio, Gherardi, Samuele, Gamble, Laura D., Wood, Katrina M., Perini, Giovanni, Lunec, John, Tweddle, Deborah A.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875109/
https://ncbi.nlm.nih.gov/pubmed/20145147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2598
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