RFWD3–Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage

In unstressed cells, the tumor suppressor p53 is maintained at low levels by ubiquitin-mediated proteolysis mainly through Mdm2. In response to DNA damage, p53 is stabilized and becomes activated to turn on transcriptional programs that are essential for cell cycle arrest and apoptosis. Activation o...

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Autori principali: Fu, Xiaoyong, Yucer, Nur, Liu, Shangfeng, Li, Muyang, Yi, Ping, Mu, Jung-Jung, Yang, Tao, Chu, Jessica, Jung, Sung Yun, O’Malley, Bert W., Gu, Wei, Qin, Jun, Wang, Yi
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842028/
https://ncbi.nlm.nih.gov/pubmed/20173098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912094107
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