RFWD3–Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage

In unstressed cells, the tumor suppressor p53 is maintained at low levels by ubiquitin-mediated proteolysis mainly through Mdm2. In response to DNA damage, p53 is stabilized and becomes activated to turn on transcriptional programs that are essential for cell cycle arrest and apoptosis. Activation o...

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Detalles Bibliográficos
Autores principales: Fu, Xiaoyong, Yucer, Nur, Liu, Shangfeng, Li, Muyang, Yi, Ping, Mu, Jung-Jung, Yang, Tao, Chu, Jessica, Jung, Sung Yun, O’Malley, Bert W., Gu, Wei, Qin, Jun, Wang, Yi
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2842028/
https://ncbi.nlm.nih.gov/pubmed/20173098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912094107
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