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RFWD3–Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage
In unstressed cells, the tumor suppressor p53 is maintained at low levels by ubiquitin-mediated proteolysis mainly through Mdm2. In response to DNA damage, p53 is stabilized and becomes activated to turn on transcriptional programs that are essential for cell cycle arrest and apoptosis. Activation o...
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| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2842028/ https://ncbi.nlm.nih.gov/pubmed/20173098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912094107 |
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