DNA topoisomerase targets of the fluoroquinolones: A strategy for avoiding bacterial resistance

Fluoroquinolones are antibacterial agents that attack DNA gyrase and topoisomerase IV on chromosomal DNA. The existence of two fluoroquinolone targets and stepwise accumulation of resistance suggested that new quinolones could be found that would require cells to obtain two topoisomerase mutations t...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Zhao, Xilin, Xu, Chen, Domagala, John, Drlica, Karl
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1997
Onderwerpen:	Biological Sciences
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28420/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9391140/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.25.13991
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