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DNA topoisomerase targets of the fluoroquinolones: A strategy for avoiding bacterial resistance

Fluoroquinolones are antibacterial agents that attack DNA gyrase and topoisomerase IV on chromosomal DNA. The existence of two fluoroquinolone targets and stepwise accumulation of resistance suggested that new quinolones could be found that would require cells to obtain two topoisomerase mutations t...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Zhao, Xilin, Xu, Chen, Domagala, John, Drlica, Karl
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28420/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9391140/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.25.13991
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