DNA topoisomerase targets of the fluoroquinolones: A strategy for avoiding bacterial resistance
Fluoroquinolones are antibacterial agents that attack DNA gyrase and topoisomerase IV on chromosomal DNA. The existence of two fluoroquinolone targets and stepwise accumulation of resistance suggested that new quinolones could be found that would require cells to obtain two topoisomerase mutations t...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1997
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28420/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9391140/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.25.13991 |
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