Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

Firefly luciferase (FLuc), an ATP-dependent bioluminescent reporter enzyme, is broadly used in chemical biology and drug discovery assays. PTC124 (Ataluren; (3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid) discovered in an FLuc-based assay targeting nonsense codon suppression, is an unusual...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Auld, Douglas S., Lovell, Scott, Thorne, Natasha, Lea, Wendy A., Maloney, David J., Shen, Min, Rai, Ganesha, Battaile, Kevin P., Thomas, Craig J., Simeonov, Anton, Hanzlik, Robert P., Inglese, James
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2010
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841876/
https://ncbi.nlm.nih.gov/pubmed/20194791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909141107
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