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A Basis for Reduced Chemical Library Inhibition of Firefly Luciferase Obtained from Directed Evolution
We measured the “druggability” of the ATP-dependent luciferase derived from the firefly Photuris pennsylvanica that was optimized using directed evolution (Ultra-Glo™, Promega). Quantitative high throughput screening (qHTS) was used to determine IC(50)’s of 198,899 samples against a formulation of U...
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| Glavni autori: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3430137/ https://ncbi.nlm.nih.gov/pubmed/19215089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8014525 |
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