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Molecular pharmacology and antitumor activity of PHT-427 a novel AKT/PDPK1 pleckstrin homology domain inhibitor

Phosphatidylinositol 3-kinase (PIK3)/ PtdIns dependent protein kinase-1(PDPK1)/Akt signaling plays a critical role in activating proliferation and survival pathways within cancer cells. We report the molecular pharmacology and antitumor activity of PHT-427 a compound designed to bind to the pleckstr...

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書誌詳細
主要な著者: Meuillet, Emmanuelle J., Zuohe, Song, Lemos, Robert, Ihle, Nathan, Kingston, John, Watkins, Ryan, Moses, Sylvestor A., Zhang, Shuxing, Cuny, Lei Du, Herbst, Roy, Jacoby, Jörg J., Zhou, Li Li, Ahad, Ali M., Mash, Eugene A, Kirkpatrick, D Lynn, Powis, Garth
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837366/
https://ncbi.nlm.nih.gov/pubmed/20197390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0985
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