Molecular pharmacology and antitumor activity of PHT-427 a novel AKT/PDPK1 pleckstrin homology domain inhibitor

Phosphatidylinositol 3-kinase (PIK3)/ PtdIns dependent protein kinase-1(PDPK1)/Akt signaling plays a critical role in activating proliferation and survival pathways within cancer cells. We report the molecular pharmacology and antitumor activity of PHT-427 a compound designed to bind to the pleckstr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Meuillet, Emmanuelle J., Zuohe, Song, Lemos, Robert, Ihle, Nathan, Kingston, John, Watkins, Ryan, Moses, Sylvestor A., Zhang, Shuxing, Cuny, Lei Du, Herbst, Roy, Jacoby, Jörg J., Zhou, Li Li, Ahad, Ali M., Mash, Eugene A, Kirkpatrick, D Lynn, Powis, Garth
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837366/
https://ncbi.nlm.nih.gov/pubmed/20197390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0985
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge