Molecular pharmacology and antitumor activity of PHT-427 a novel AKT/PDPK1 pleckstrin homology domain inhibitor

Phosphatidylinositol 3-kinase (PIK3)/ PtdIns dependent protein kinase-1(PDPK1)/Akt signaling plays a critical role in activating proliferation and survival pathways within cancer cells. We report the molecular pharmacology and antitumor activity of PHT-427 a compound designed to bind to the pleckstr...

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Hlavní autoři: Meuillet, Emmanuelle J., Zuohe, Song, Lemos, Robert, Ihle, Nathan, Kingston, John, Watkins, Ryan, Moses, Sylvestor A., Zhang, Shuxing, Cuny, Lei Du, Herbst, Roy, Jacoby, Jörg J., Zhou, Li Li, Ahad, Ali M., Mash, Eugene A, Kirkpatrick, D Lynn, Powis, Garth
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837366/
https://ncbi.nlm.nih.gov/pubmed/20197390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0985
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