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Development of sulfonamide AKT PH domain inhibitors
Disruption of the phosphatidylinositol 3-kinase/AKT signaling pathway can lead to apoptosis in cancer cells. Previously we identified a lead sulfonamide that selectively bound to the pleckstrin homology (PH) domain of AKT and induced apoptosis when present at low micromolar concentrations. To examin...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3088502/ https://ncbi.nlm.nih.gov/pubmed/21353784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.01.049 |
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