Development of sulfonamide AKT PH domain inhibitors

Disruption of the phosphatidylinositol 3-kinase/AKT signaling pathway can lead to apoptosis in cancer cells. Previously we identified a lead sulfonamide that selectively bound to the pleckstrin homology (PH) domain of AKT and induced apoptosis when present at low micromolar concentrations. To examin...

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Detalhes bibliográficos
Main Authors: Ahad, Ali Md., Zuohe, Song, Du-Cuny, Lei, Moses, Sylvestor A., Zhou, Li Li, Zhang, Shuxing, Powis, Garth, Meuillet, Emmanuelle J., Mash, Eugene A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088502/
https://ncbi.nlm.nih.gov/pubmed/21353784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.01.049
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