Molecular pharmacology and antitumor activity of PHT-427 a novel AKT/PDPK1 pleckstrin homology domain inhibitor

Phosphatidylinositol 3-kinase (PIK3)/ PtdIns dependent protein kinase-1(PDPK1)/Akt signaling plays a critical role in activating proliferation and survival pathways within cancer cells. We report the molecular pharmacology and antitumor activity of PHT-427 a compound designed to bind to the pleckstr...

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Detalhes bibliográficos
Main Authors: Meuillet, Emmanuelle J., Zuohe, Song, Lemos, Robert, Ihle, Nathan, Kingston, John, Watkins, Ryan, Moses, Sylvestor A., Zhang, Shuxing, Cuny, Lei Du, Herbst, Roy, Jacoby, Jörg J., Zhou, Li Li, Ahad, Ali M., Mash, Eugene A, Kirkpatrick, D Lynn, Powis, Garth
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837366/
https://ncbi.nlm.nih.gov/pubmed/20197390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0985
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