Novel Inhibitors Induce Large Conformational Changes of GAB1 Pleckstrin Homology Domain and Kill Breast Cancer Cells

The Grb2-associated binding protein 1 (GAB1) integrates signals from different signaling pathways and is over-expressed in many cancers, therefore representing a new therapeutic target. In the present study, we aim to target the pleckstrin homology (PH) domain of GAB1 for cancer treatment. Using hom...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Chen, Lu, Du-Cuny, Lei, Moses, Sylvestor, Dumas, Sabrina, Song, Zuohe, Rezaeian, Abdol Hossein, Lin, Hui-Kuan, Meuillet, Emmanuelle J., Zhang, Shuxing
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287437/
https://ncbi.nlm.nih.gov/pubmed/25569504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004021
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