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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain
Computational modeling continues to play an important role in novel therapeutics discovery and development. In this study, we have investigated the use of in silico approaches to develop inhibitors of the pleckstrin homology (PH) domain of AKT (protein kinase B). Various docking/scoring schemes have...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2808703/ https://ncbi.nlm.nih.gov/pubmed/19734051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.08.022 |
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