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Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain

Computational modeling continues to play an important role in novel therapeutics discovery and development. In this study, we have investigated the use of in silico approaches to develop inhibitors of the pleckstrin homology (PH) domain of AKT (protein kinase B). Various docking/scoring schemes have...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Du-Cuny, Lei, Zuohe, Song, Moses, Sylvestor, Powis, Garth, Mash, Eugene A., Meuillet, Emmanuelle J., Zhang, Shuxing
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808703/
https://ncbi.nlm.nih.gov/pubmed/19734051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.08.022
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