In vitro and In vivo Activity of Novel Small-Molecule Inhibitors Targeting the Pleckstrin Homology Domain of Protein Kinase B/AKT

The phosphatidylinositol 3-kinase/AKT signaling pathway plays a critical role in activating survival and antiapoptotic pathways within cancer cells. Several studies have shown that this pathway is constitutively activated in many different cancer types. The goal of this study was to discover novel c...

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Detalhes bibliográficos
Main Authors: Moses, Sylvestor A., Ali, M. Ahad, Zuohe, Song, Du-Cuny, Lei, Zhou, Li Li, Lemos, Robert, Ihle, Nathan, Skillman, A. Geoffrey, Zhang, Shuxing, Mash, Eugene A., Powis, Garth, Meuillet, Emmanuelle J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914301/
https://ncbi.nlm.nih.gov/pubmed/19491272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3839
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