Synthetic amyloid-β oligomers impair long-term memory independently of cellular prion protein

Inability to form new memories is an early clinical sign of Alzheimer’s disease (AD). There is ample evidence that the amyloid-β (Aβ) peptide plays a key role in the pathogenesis of this disorder. Soluble, bio-derived oligomers of Aβ are proposed as the key mediators of synaptic and cognitive dysfun...

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Bibliografiske detaljer
Main Authors: Balducci, Claudia, Beeg, Marten, Stravalaci, Matteo, Bastone, Antonio, Sclip, Alessandra, Biasini, Emiliano, Tapella, Laura, Colombo, Laura, Manzoni, Claudia, Borsello, Tiziana, Chiesa, Roberto, Gobbi, Marco, Salmona, Mario, Forloni, Gianluigi
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836680/
https://ncbi.nlm.nih.gov/pubmed/20133875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911829107
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