T7 phage protein Gp2 inhibits the Escherichia coli RNA polymerase by antagonizing stable DNA strand separation near the transcription start site

Infection of Escherichia coli by the T7 phage leads to rapid and selective inhibition of the host RNA polymerase (RNAP)—a multi-subunit enzyme responsible for gene transcription—by a small (∼7 kDa) phage-encoded protein called Gp2. Gp2 is also a potent inhibitor of E. coli RNAP in vitro. Here we des...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Cámara, Beatriz, Liu, Minhao, Reynolds, Jonathan, Shadrin, Andrey, Liu, Bing, Kwok, King, Simpson, Peter, Weinzierl, Robert, Severinov, Konstantin, Cota, Ernesto, Matthews, Steve, Wigneshweraraj, Siva R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2010
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836649/
https://ncbi.nlm.nih.gov/pubmed/20133868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907908107
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