T7 phage protein Gp2 inhibits the Escherichia coli RNA polymerase by antagonizing stable DNA strand separation near the transcription start site

Infection of Escherichia coli by the T7 phage leads to rapid and selective inhibition of the host RNA polymerase (RNAP)—a multi-subunit enzyme responsible for gene transcription—by a small (∼7 kDa) phage-encoded protein called Gp2. Gp2 is also a potent inhibitor of E. coli RNAP in vitro. Here we des...

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Detalhes bibliográficos
Main Authors: Cámara, Beatriz, Liu, Minhao, Reynolds, Jonathan, Shadrin, Andrey, Liu, Bing, Kwok, King, Simpson, Peter, Weinzierl, Robert, Severinov, Konstantin, Cota, Ernesto, Matthews, Steve, Wigneshweraraj, Siva R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836649/
https://ncbi.nlm.nih.gov/pubmed/20133868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907908107
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