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Substitutions in the Escherichia coli RNA polymerase inhibitor T7 Gp2 that allow inhibition of transcription when the primary interaction interface between Gp2 and RNA polymerase becomes compromised

The Escherichia coli-infecting bacteriophage T7 encodes a 7 kDa protein, called Gp2, which is a potent inhibitor of the host RNA polymerase (RNAp). Gp2 is essential for T7 phage development. The interaction site for Gp2 on the E. coli RNAp is the β′ jaw domain, which is part of the DNA binding chann...

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Detalhes bibliográficos
Main Authors: Shadrin, Andrey, Sheppard, Carol, Severinov, Konstantin, Matthews, Steve, Wigneshweraraj, Sivaramesh
Formato: Artigo
Idioma:Inglês
Publicado em: Society for General Microbiology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3541766/
https://ncbi.nlm.nih.gov/pubmed/22977089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/mic.0.062547-0
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