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Molecular mechanism of transcription inhibition by phage T7 gp2 protein
E. coli T7 bacteriophage gp2 protein is a potent inhibitor of host RNA polymerase (RNAP). Gp2 inhibits formation of open promoter complex by binding to the β′ jaw, an RNAP domain that interacts with downstream promoter DNA. Here, we used an engineered promoter with an optimized sequence to obtain an...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3217721/ https://ncbi.nlm.nih.gov/pubmed/21963987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.09.029 |
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