Structural and Mechanistic Basis for the Inhibition of Escherichia coli RNA Polymerase by T7 Gp2

The T7 phage-encoded small protein Gp2 is a non-DNA-binding transcription factor that interacts with the jaw domain of the Escherichia coli (Ec) RNA polymerase (RNAp) β′ subunit and inhibits transcriptionally proficient promoter-complex (RPo) formation. Here, we describe the high-resolution solution...

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Detalhes bibliográficos
Main Authors: James, Ellen, Liu, Minhao, Sheppard, Carol, Mekler, Vladimir, Cámara, Beatriz, Liu, Bing, Simpson, Pete, Cota, Ernesto, Severinov, Konstantin, Matthews, Steve, Wigneshweraraj, Sivaramesh
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778932/
https://ncbi.nlm.nih.gov/pubmed/22819324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.06.013
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