Allele-specific RNAi Mitigates Phenotypic Progression in a Transgenic Model of Alzheimer's Disease

Despite recent advances suggesting new therapeutic targets, Alzheimer's disease (AD) remains incurable. Aberrant production and accumulation of the Aβ peptide resulting from altered processing of the amyloid precursor protein (APP) is central to the pathogenesis of disease, particularly in domi...

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Autori principali: Rodríguez-Lebrón, Edgardo, Gouvion, Cynthia M, Moore, Steven A, Davidson, Beverly L, Paulson, Henry L
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2009
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835271/
https://ncbi.nlm.nih.gov/pubmed/19532137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.123
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