Allele-specific silencing of dominant disease genes

Small interfering RNA (siRNA) holds therapeutic promise for silencing dominantly acting disease genes, particularly if mutant alleles can be targeted selectively. In mammalian cell models we demonstrate that allele-specific silencing of disease genes with siRNA can be achieved by targeting either a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Miller, Victor M., Xia, Haibin, Marrs, Ginger L., Gouvion, Cynthia M., Lee, Gloria, Davidson, Beverly L., Paulson, Henry L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2003
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC165852/
https://ncbi.nlm.nih.gov/pubmed/12782788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1231012100
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