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Allele-specific silencing of dominant disease genes
Small interfering RNA (siRNA) holds therapeutic promise for silencing dominantly acting disease genes, particularly if mutant alleles can be targeted selectively. In mammalian cell models we demonstrate that allele-specific silencing of disease genes with siRNA can be achieved by targeting either a...
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| Main Authors: | , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC165852/ https://ncbi.nlm.nih.gov/pubmed/12782788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1231012100 |
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