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Allele-Specific Gene Silencing in Two Mouse Models of Autosomal Dominant Skeletal Myopathy

We explored the potential of mutant allele-specific gene silencing (ASGS) in providing therapeutic benefit in two established mouse models of the autosomal dominantly-inherited muscle disorders, Malignant Hyperthermia (MH) and Central Core Disease (CCD). Candidate ASGS siRNAs were designed and valid...

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Библиографические подробности
Главные авторы: Loy, Ryan E., Lueck, John D., Mostajo-Radji, Mohammed A., Carrell, Ellie M., Dirksen, Robert T.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495761/
https://ncbi.nlm.nih.gov/pubmed/23152933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049757
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