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Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles

Tau and amyloid precursor protein (APP) are key proteins in the pathogenesis of sporadic and inherited Alzheimer’s disease. Thus, developing ways to inhibit production of these proteins is of great research and therapeutic interest. The selective silencing of mutant alleles, moreover, represents an...

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Bibliografiske detaljer
Main Authors: Miller, Victor M., Gouvion, Cynthia M., Davidson, Beverly L., Paulson, Henry L.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC373334/
https://ncbi.nlm.nih.gov/pubmed/14754988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh208
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