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Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles

Tau and amyloid precursor protein (APP) are key proteins in the pathogenesis of sporadic and inherited Alzheimer’s disease. Thus, developing ways to inhibit production of these proteins is of great research and therapeutic interest. The selective silencing of mutant alleles, moreover, represents an...

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Détails bibliographiques
Auteurs principaux: Miller, Victor M., Gouvion, Cynthia M., Davidson, Beverly L., Paulson, Henry L.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2004
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC373334/
https://ncbi.nlm.nih.gov/pubmed/14754988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh208
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