Specific Silencing of L392V PSEN1 Mutant Allele by RNA Interference

RNA interference (RNAi) technology provides a powerful molecular tool to reduce an expression of selected genes in eukaryotic cells. Short interfering RNAs (siRNAs) are the effector molecules that trigger RNAi. Here, we describe siRNAs that discriminate between the wild type and mutant (1174 C→G) al...

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Detalhes bibliográficos
Main Authors: Sierant, Malgorzata, Paduszynska, Alina, Kazmierczak-Baranska, Julia, Nacmias, Benedetta, Sorbi, Sandro, Bagnoli, Silvia, Sochacka, Elzbieta, Nawrot, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090069/
https://ncbi.nlm.nih.gov/pubmed/21559198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/809218
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